Advances in synthetic approach to and antifungal activity of triazoles

• Kumari Shalini,
• Nitin Kumar,
• Sushma Drabu and
• Pramod Kumar Sharma

Beilstein J. Org. Chem. 2011, 7, 668–677, doi:10.3762/bjoc.7.79

• exhibit a broad spectrum of pharmacological activity such as antifungal, antibacterial, anti-inflammatory and anticancer etc. Triazoles have increased our ability to treat many fungal infections, for example, candidiasis, cryptococcal meningitis, aspergillosis etc. However, mortality due to these

• we are entering a new era of antifungal therapy in which we will continue to be challenged by systemic fungal diseases, the options for treatment will have greatly expanded. Keywords: antifungal; aspergillosis; candidiasis; cryptococcal meningitis; triazole; Review Introduction The alarming rates

• meningitis, cryptococcal meningitis, systemic and mucosal candidiasis in both normal and immune compromised patients, coccidioidal meningitis, histoplasmosis and infections due to chemotherapy or radiation therapy prior to a bone marrow transplant [44][45][46]. Itraconazole Itraconazole (10, Figure 9) has